Structural insights into binding of STAC proteins to voltage-gated calcium channels.

Excitation-contraction (EC) coupling in skeletal muscle requires purposeful and mechanical coupling between L-type voltage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1). Recently, STAC3 was recognized as an important protein for EC coupling and is an element of a gaggle of three proteins that may bind and modulate L-type voltage-gated calcium channels.

Here, we report crystal constructions of tandem-SH3 domains of completely different STAC isoforms up to 1.2-Å decision. These type a inflexible interplay by means of a conserved interdomain interface. We determine the linker connecting transmembrane repeats II and III in two completely different CaV isoforms as a binding website for the SH3 domains and report a crystal construction of the complicated with the STAC2 isoform.

The interplay website contains the placement for a illness variant in STAC3 that has been linked to Native American myopathy (NAM). Introducing the mutation doesn’t trigger misfolding of the SH3 domains, however abolishes the interplay. Disruption of the interplay through mutations within the II-III loop perturbs skeletal muscle EC coupling, however preserves the flexibility of STAC3 to decelerate inactivation of CaV1.2.

Calcium waves in a grid of clustered channels with synchronous IP3 binding and unbinding.

Calcium indicators in cells happen at a number of spatial scales and variable temporal length. However, a bodily rationalization for transitions between long-lasting international oscillations and localized short-term elevations (puffs) of cytoplasmic Ca2+ remains to be missing.

Here we introduce a phenomenological, coarse-grained mannequin for the calcium variable, which is represented by bizarre differential equations. Due to its small quantity of parameters, and its simplicity, this mannequin permits us to numerically research the interaction of multi-scale calcium concentrations with stochastic ion channel gating dynamics even in bigger techniques.

ANK1 Peptide

46-725P ProSci 0.1 mg 338 EUR
Description: Ankyrin 1 / ANK1 Peptide

ANK1 cloning plasmid

CSB-CL001720HU1-10ug Cusabio 10ug 233 EUR
Description: A cloning plasmid for the ANK1 gene.

ANK1 cloning plasmid

CSB-CL001720HU2-10ug Cusabio 10ug 233 EUR
Description: A cloning plasmid for the ANK1 gene.

Mouse ANK1 shRNA Plasmid

20-abx969140 Abbexa
  • 801.00 EUR
  • 1121.00 EUR
  • 150 µg
  • 300 µg

Human ANK1 shRNA Plasmid

20-abx950199 Abbexa
  • 801.00 EUR
  • 1121.00 EUR
  • 150 µg
  • 300 µg

Ankyrin 1 (ANK1) Antibody

abx037600-100ug Abbexa 100 ug 391 EUR

Ankyrin R (ANK1) Antibody

abx445096-100ug Abbexa 100 ug 523 EUR

Ankyrin 1 (ANK1) Antibody

abx430864-200ul Abbexa 200 ul 286 EUR

ANK1 ELISA KIT|Human

EF004617 Lifescience Market 96 Tests 689 EUR

Recombinant Ankyrin 1, Erythrocytic (ANK1)

4-RPB633Hu01 Cloud-Clone
  • 476.32 EUR
  • 230.00 EUR
  • 1511.20 EUR
  • 570.40 EUR
  • 1040.80 EUR
  • 382.00 EUR
  • 3628.00 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Ankyrin 1, Erythrocytic expressed in: E.coli

Polyclonal ANK1 antibody - middle region

APR00810G Leading Biology 0.05mg 528 EUR
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ANK1 - middle region. This antibody is tested and proven to work in the following applications:

Ankyrin 1, Erythrocytic (ANK1) Antibody

20-abx128802 Abbexa
  • 411.00 EUR
  • 133.00 EUR
  • 1149.00 EUR
  • 565.00 EUR
  • 314.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ankyrin R (ANK1) Antibody (ALP)

abx442493-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (APC)

abx442774-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (Biotin)

abx443054-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (FITC)

abx443334-100ug Abbexa 100 ug 565 EUR

Ankyrin R (ANK1) Antibody (HRP)

abx443615-100ug Abbexa 100 ug 565 EUR

Ankyrin R (ANK1) Antibody (PerCP)

abx444177-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (RPE)

abx444458-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (Streptavidin)

abx444739-100ug Abbexa 100 ug 578 EUR

Anti-Ankyrin 1 / ANK1 antibody

STJ71553 St John's Laboratory 100 µg 260 EUR

ANK1 ORF Vector (Human) (pORF)

ORF000405 ABM 1.0 ug DNA 95 EUR

ANK1 ORF Vector (Human) (pORF)

ORF000406 ABM 1.0 ug DNA 95 EUR

Ank1 ORF Vector (Mouse) (pORF)

ORF038594 ABM 1.0 ug DNA 1572 EUR

Ank1 ORF Vector (Mouse) (pORF)

ORF038595 ABM 1.0 ug DNA 1572 EUR

Ank1 ORF Vector (Rat) (pORF)

ORF063392 ABM 1.0 ug DNA 2080 EUR

Human Ankyrin 1 (ANK1) ELISA Kit

abx384586-96tests Abbexa 96 tests 911 EUR

Human Ankyrin 1, Erythrocytic (ANK1) Protein

20-abx168126 Abbexa
  • 662.00 EUR
  • 272.00 EUR
  • 2040.00 EUR
  • 787.00 EUR
  • 481.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Ankyrin 1 (ANK1) ELISA Kit

abx388583-96tests Abbexa 96 tests 911 EUR

Ankyrin R (ANK1) Antibody (ATTO 390)

abx440245-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 488)

abx440526-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 565)

abx440807-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 594)

abx441088-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 633)

abx441369-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 655)

abx441650-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 680)

abx441931-100ug Abbexa 100 ug 578 EUR

Ankyrin R (ANK1) Antibody (ATTO 700)

abx442212-100ug Abbexa 100 ug 578 EUR

Mouse Ankyrin- 1, Ank1 ELISA KIT

ELI-49245m Lifescience Market 96 Tests 865 EUR

Human Ankyrin- 1, ANK1 ELISA KIT

ELI-49312h Lifescience Market 96 Tests 824 EUR

ANK1 sgRNA CRISPR Lentivector set (Human)

K0086301 ABM 3 x 1.0 ug 339 EUR

Ank1 sgRNA CRISPR Lentivector set (Rat)

K6307301 ABM 3 x 1.0 ug 339 EUR

Rat Ankyrin 1(ANK1) ELISA kit

E02A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Rat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ankyrin 1(ANK1) ELISA kit

E02A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Rat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ankyrin 1(ANK1) ELISA kit

E02A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Rat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ank1 sgRNA CRISPR Lentivector set (Mouse)

K3878001 ABM 3 x 1.0 ug 339 EUR

Monkey Ankyrin 1(ANK1) ELISA kit

E09A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Monkey Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ankyrin 1(ANK1) ELISA kit

E09A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Monkey Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ankyrin 1(ANK1) ELISA kit

E09A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Monkey Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ankyrin 1(ANK1) ELISA kit

E08A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Canine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ankyrin 1(ANK1) ELISA kit

E08A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Canine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ankyrin 1(ANK1) ELISA kit

E08A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Canine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ankyrin 1(ANK1) ELISA kit

E01A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Human Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ankyrin 1(ANK1) ELISA kit

E01A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Human Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ankyrin 1(ANK1) ELISA kit

E01A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Human Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ankyrin 1(ANK1) ELISA kit

E04A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ankyrin 1(ANK1) ELISA kit

E04A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ankyrin 1(ANK1) ELISA kit

E04A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ankyrin 1(ANK1) ELISA kit

E03A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Mouse Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ankyrin 1(ANK1) ELISA kit

E03A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Mouse Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ankyrin 1(ANK1) ELISA kit

E03A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Mouse Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ankyrin 1(ANK1) ELISA kit

E07A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Porcine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ankyrin 1(ANK1) ELISA kit

E07A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Porcine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ankyrin 1(ANK1) ELISA kit

E07A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Porcine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ankyrin 1(ANK1) ELISA kit

E06A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Goat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ankyrin 1(ANK1) ELISA kit

E06A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Goat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ankyrin 1(ANK1) ELISA kit

E06A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Goat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human)

4-PAB633Hu01 Cloud-Clone
  • 239.00 EUR
  • 2391.00 EUR
  • 598.00 EUR
  • 299.00 EUR
  • 211.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1)

Polyclonal Ankyrin 1 / ANK1 Antibody (C-Term)

APG00534G Leading Biology 0.1mg 484 EUR
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Ankyrin 1 / ANK1 (C-Term). This antibody is tested and proven to work in the following applications:

Ankyrin R (ANK1) Antibody (PE/ATTO 594)

abx443896-100ug Abbexa 100 ug 592 EUR

ANK1 sgRNA CRISPR Lentivector (Human) (Target 1)

K0086302 ABM 1.0 ug DNA 154 EUR

ANK1 sgRNA CRISPR Lentivector (Human) (Target 2)

K0086303 ABM 1.0 ug DNA 154 EUR

ANK1 sgRNA CRISPR Lentivector (Human) (Target 3)

K0086304 ABM 1.0 ug DNA 154 EUR

Ank1 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6307302 ABM 1.0 ug DNA 154 EUR

Ank1 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6307303 ABM 1.0 ug DNA 154 EUR

Ank1 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6307304 ABM 1.0 ug DNA 154 EUR

Ank1 3'UTR Luciferase Stable Cell Line

TU101791 ABM 1.0 ml Ask for price

ANK1 Protein Vector (Mouse) (pPB-C-His)

PV154374 ABM 500 ng 3068 EUR

ANK1 Protein Vector (Mouse) (pPB-N-His)

PV154375 ABM 500 ng 3068 EUR

ANK1 Protein Vector (Mouse) (pPM-C-HA)

PV154376 ABM 500 ng 3068 EUR

ANK1 Protein Vector (Mouse) (pPM-C-His)

PV154377 ABM 500 ng 3068 EUR

ANK1 Protein Vector (Mouse) (pPB-C-His)

PV154378 ABM 500 ng 3157 EUR

ANK1 Protein Vector (Mouse) (pPB-N-His)

PV154379 ABM 500 ng 3157 EUR

ANK1 Protein Vector (Mouse) (pPM-C-HA)

PV154380 ABM 500 ng 3157 EUR

ANK1 Protein Vector (Mouse) (pPM-C-His)

PV154381 ABM 500 ng 3157 EUR

Ank1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3878002 ABM 1.0 ug DNA 154 EUR

Ank1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3878003 ABM 1.0 ug DNA 154 EUR

Ank1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3878004 ABM 1.0 ug DNA 154 EUR

ANK1 Protein Vector (Human) (pPB-His-MBP)

PV321786 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPB-His-GST)

PV321787 ABM 500 ng 329 EUR

ANK1 Protein Vector (Rat) (pPB-C-His)

PV253566 ABM 500 ng 2853 EUR

ANK1 Protein Vector (Rat) (pPB-N-His)

PV253567 ABM 500 ng 2853 EUR

ANK1 Protein Vector (Rat) (pPM-C-HA)

PV253568 ABM 500 ng 2853 EUR

ANK1 Protein Vector (Rat) (pPM-C-His)

PV253569 ABM 500 ng 2853 EUR

ANK1 Protein Vector (Human) (pPB-C-His)

PV001617 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPB-N-His)

PV001618 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPM-C-HA)

PV001619 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPM-C-His)

PV001620 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPB-C-His)

PV001621 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPB-N-His)

PV001622 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPM-C-HA)

PV001623 ABM 500 ng 329 EUR

ANK1 Protein Vector (Human) (pPM-C-His)

PV001624 ABM 500 ng 329 EUR

Ank1 3'UTR GFP Stable Cell Line

TU250614 ABM 1.0 ml Ask for price

Ank1 3'UTR Luciferase Stable Cell Line

TU200614 ABM 1.0 ml Ask for price

ANK1 3'UTR GFP Stable Cell Line

TU050757 ABM 1.0 ml 1521 EUR

Ank1 3'UTR GFP Stable Cell Line

TU151791 ABM 1.0 ml Ask for price

ANK1 3'UTR Luciferase Stable Cell Line

TU000757 ABM 1.0 ml 1521 EUR

Guinea pig Ankyrin 1(ANK1) ELISA kit

E05A1448-192T BlueGene 192 tests 1270 EUR
Description: A sandwich ELISA for quantitative measurement of Guinea pig Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Ankyrin 1(ANK1) ELISA kit

E05A1448-48 BlueGene 1 plate of 48 wells 520 EUR
Description: A sandwich ELISA for quantitative measurement of Guinea pig Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Ankyrin 1(ANK1) ELISA kit

E05A1448-96 BlueGene 1 plate of 96 wells 685 EUR
Description: A sandwich ELISA for quantitative measurement of Guinea pig Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), APC

4-PAB633Hu01-APC Cloud-Clone
  • 333.00 EUR
  • 3113.00 EUR
  • 872.00 EUR
  • 423.00 EUR
  • 215.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with APC.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), Biotinylated

4-PAB633Hu01-Biotin Cloud-Clone
  • 303.00 EUR
  • 2341.00 EUR
  • 697.00 EUR
  • 369.00 EUR
  • 216.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with Biotin.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), Cy3

4-PAB633Hu01-Cy3 Cloud-Clone
  • 403.00 EUR
  • 4109.00 EUR
  • 1121.00 EUR
  • 523.00 EUR
  • 245.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with Cy3.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), FITC

4-PAB633Hu01-FITC Cloud-Clone
  • 287.00 EUR
  • 2510.00 EUR
  • 717.00 EUR
  • 359.00 EUR
  • 192.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with FITC.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), HRP

4-PAB633Hu01-HRP Cloud-Clone
  • 305.00 EUR
  • 2714.00 EUR
  • 772.00 EUR
  • 383.00 EUR
  • 203.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with HRP.

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), PE

4-PAB633Hu01-PE Cloud-Clone
  • 287.00 EUR
  • 2510.00 EUR
  • 717.00 EUR
  • 359.00 EUR
  • 192.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with PE.

Ank1 ELISA Kit| Mouse Ankyrin-1 ELISA Kit

EF014208 Lifescience Market 96 Tests 689 EUR

ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV669001 ABM 1.0 ug DNA 2659 EUR

ANK1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV669005 ABM 1.0 ug DNA 2659 EUR

ANK1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV669006 ABM 1.0 ug DNA 2659 EUR

ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV707337 ABM 1.0 ug DNA 316 EUR

ANK1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV707341 ABM 1.0 ug DNA 316 EUR

ANK1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV707342 ABM 1.0 ug DNA 316 EUR

Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), APC-Cy7

4-PAB633Hu01-APC-Cy7 Cloud-Clone
  • 547.00 EUR
  • 6106.00 EUR
  • 1624.00 EUR
  • 727.00 EUR
  • 310.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with APC-Cy7.

ANK1 Protein Vector (Human) (pPM-N-D-C-HA)

PV321788 ABM 500 ng 552 EUR

ANK1 Protein Vector (Human) (pPM-N-D-C-His)

PV321789 ABM 500 ng 552 EUR

ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0086305 ABM 3 x 1.0 ug 376 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6307305 ABM 3 x 1.0 ug 376 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3878005 ABM 3 x 1.0 ug 376 EUR

ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0086306 ABM 1.0 ug DNA 167 EUR

ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0086307 ABM 1.0 ug DNA 167 EUR

ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0086308 ABM 1.0 ug DNA 167 EUR

ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV669002 ABM 1.0 ug DNA 2659 EUR

ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV669003 ABM 1.0 ug DNA 2717 EUR

ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV669004 ABM 1.0 ug DNA 2717 EUR

ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV707338 ABM 1.0 ug DNA 316 EUR

ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV707339 ABM 1.0 ug DNA 374 EUR

ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV707340 ABM 1.0 ug DNA 374 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6307306 ABM 1.0 ug DNA 167 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6307307 ABM 1.0 ug DNA 167 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6307308 ABM 1.0 ug DNA 167 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3878006 ABM 1.0 ug DNA 167 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3878007 ABM 1.0 ug DNA 167 EUR

Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3878008 ABM 1.0 ug DNA 167 EUR

We apply this mannequin to a single cluster of inositol trisphosphate (IP 3) receptor channels and discover additional proof for the outcomes introduced in earlier work: a single cluster could also be succesful of producing completely different calcium launch sorts, the place long-lasting occasions are accompanied by unbinding of IP Three from the receptor (Rückl et al., PLoS Comput. Biol. 11, e1003965 (2015)).

Finally, we present the practicability of the mannequin in a grid of 64 clusters which is computationally intractable with earlier high-resolution fashions. Here long-lasting occasions can lead to synchronized oscillations and waves, whereas brief occasions keep localized. The frequency of calcium releases in addition to their coherence can thereby be regulated by the amplitude of IP Three stimulation. Finally the mannequin permits for a brand new rationalization of oscillating [IP 3], which isn’t based mostly on metabolic manufacturing and degradation of IP 3.

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