Structural insights into binding of STAC proteins to voltage-gated calcium channels.
Excitation-contraction (EC) coupling in skeletal muscle requires purposeful and mechanical coupling between L-type voltage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1). Recently, STAC3 was recognized as an important protein for EC coupling and is an element of a gaggle of three proteins that may bind and modulate L-type voltage-gated calcium channels.
Here, we report crystal constructions of tandem-SH3 domains of completely different STAC isoforms up to 1.2-Å decision. These type a inflexible interplay by means of a conserved interdomain interface. We determine the linker connecting transmembrane repeats II and III in two completely different CaV isoforms as a binding website for the SH3 domains and report a crystal construction of the complicated with the STAC2 isoform.
The interplay website contains the placement for a illness variant in STAC3 that has been linked to Native American myopathy (NAM). Introducing the mutation doesn’t trigger misfolding of the SH3 domains, however abolishes the interplay. Disruption of the interplay through mutations within the II-III loop perturbs skeletal muscle EC coupling, however preserves the flexibility of STAC3 to decelerate inactivation of CaV1.2.
Calcium waves in a grid of clustered channels with synchronous IP3 binding and unbinding.
Calcium indicators in cells happen at a number of spatial scales and variable temporal length. However, a bodily rationalization for transitions between long-lasting international oscillations and localized short-term elevations (puffs) of cytoplasmic Ca2+ remains to be missing.
Here we introduce a phenomenological, coarse-grained mannequin for the calcium variable, which is represented by bizarre differential equations. Due to its small quantity of parameters, and its simplicity, this mannequin permits us to numerically research the interaction of multi-scale calcium concentrations with stochastic ion channel gating dynamics even in bigger techniques.
ANK1 siRNA |
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20-abx907484 | Abbexa |
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ANK1 cloning plasmid |
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CSB-CL001720HU1-10ug | Cusabio | 10ug | 279.6 EUR |
Description: A cloning plasmid for the ANK1 gene. |
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ANK1 cloning plasmid |
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CSB-CL001720HU2-10ug | Cusabio | 10ug | 279.6 EUR |
Description: A cloning plasmid for the ANK1 gene. |
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Human ANK1 shRNA Plasmid |
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20-abx950199 | Abbexa |
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Mouse ANK1 shRNA Plasmid |
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20-abx969140 | Abbexa |
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Ankyrin 1 (ANK1) Antibody |
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abx037600-100ug | Abbexa | 100 ug | 469.2 EUR |
Ankyrin 1 (ANK1) Antibody |
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abx430864-200ul | Abbexa | 200 ul | 343.2 EUR |
Ankyrin R (ANK1) Antibody |
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abx445096-100ug | Abbexa | 100 ug | 627.6 EUR |
ANK1 ELISA KIT|Human |
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EF004617 | Lifescience Market | 96 Tests | 826.8 EUR |
Ankyrin 1, Erythrocytic (ANK1) Antibody |
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20-abx128802 | Abbexa |
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Ankyrin R (ANK1) Antibody (APC) |
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abx442774-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (Biotin) |
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abx443054-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (FITC) |
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abx443334-100ug | Abbexa | 100 ug | 678 EUR |
Ankyrin R (ANK1) Antibody (HRP) |
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abx443615-100ug | Abbexa | 100 ug | 678 EUR |
Ankyrin R (ANK1) Antibody (PerCP) |
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abx444177-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (RPE) |
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abx444458-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (Streptavidin) |
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abx444739-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ALP) |
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abx442493-100ug | Abbexa | 100 ug | 693.6 EUR |
Polyclonal ANK1 antibody - middle region |
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APR00810G | Leading Biology | 0.05mg | 633.6 EUR |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ANK1 - middle region. This antibody is tested and proven to work in the following applications: |
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Ank1 ORF Vector (Rat) (pORF) |
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ORF063392 | ABM | 1.0 ug DNA | 2496 EUR |
ANK1 ORF Vector (Human) (pORF) |
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ORF000405 | ABM | 1.0 ug DNA | 114 EUR |
ANK1 ORF Vector (Human) (pORF) |
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ORF000406 | ABM | 1.0 ug DNA | 114 EUR |
Ank1 ORF Vector (Mouse) (pORF) |
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ORF038594 | ABM | 1.0 ug DNA | 1886.4 EUR |
Ank1 ORF Vector (Mouse) (pORF) |
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ORF038595 | ABM | 1.0 ug DNA | 1886.4 EUR |
Anti-Ankyrin 1 / ANK1 antibody |
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STJ71553 | St John's Laboratory | 100 µg | 312 EUR |
Recombinant Ankyrin 1, Erythrocytic (ANK1) |
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4-RPB633Hu01 | Cloud-Clone |
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Description: Recombinant Human Ankyrin 1, Erythrocytic expressed in: E.coli |
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Human Ankyrin 1(ANK1) ELISA kit |
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E01A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Human Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ankyrin 1(ANK1) ELISA kit |
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E01A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Human Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ankyrin 1(ANK1) ELISA kit |
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E01A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Human Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ankyrin 1(ANK1) ELISA kit |
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E02A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Rat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ankyrin 1(ANK1) ELISA kit |
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E02A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Rat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ankyrin 1(ANK1) ELISA kit |
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E02A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Rat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ankyrin 1(ANK1) ELISA kit |
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E07A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Porcine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ankyrin 1(ANK1) ELISA kit |
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E07A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Porcine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ankyrin 1(ANK1) ELISA kit |
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E07A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Porcine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ankyrin 1(ANK1) ELISA kit |
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E04A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Rabbit Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ankyrin 1(ANK1) ELISA kit |
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E04A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Rabbit Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ankyrin 1(ANK1) ELISA kit |
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E04A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Rabbit Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ankyrin 1(ANK1) ELISA kit |
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E08A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Canine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ankyrin 1(ANK1) ELISA kit |
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E08A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Canine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ankyrin 1(ANK1) ELISA kit |
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E08A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Canine Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ankyrin 1(ANK1) ELISA kit |
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E09A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Monkey Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ankyrin 1(ANK1) ELISA kit |
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E09A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Monkey Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ankyrin 1(ANK1) ELISA kit |
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E09A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Monkey Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ankyrin 1(ANK1) ELISA kit |
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E06A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Goat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ankyrin 1(ANK1) ELISA kit |
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E06A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Goat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ankyrin 1(ANK1) ELISA kit |
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E06A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Goat Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ankyrin 1(ANK1) ELISA kit |
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E03A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Mouse Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ankyrin 1(ANK1) ELISA kit |
|||
E03A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Mouse Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Mouse Ankyrin 1(ANK1) ELISA kit |
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E03A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Mouse Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ankyrin 1, Erythrocytic (ANK1) Protein |
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20-abx168126 | Abbexa |
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Human Ankyrin 1 (ANK1) ELISA Kit |
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abx384586-96tests | Abbexa | 96 tests | 1093.2 EUR |
Mouse Ankyrin 1 (ANK1) ELISA Kit |
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abx388583-96tests | Abbexa | 96 tests | 1093.2 EUR |
Ankyrin R (ANK1) Antibody (ATTO 390) |
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abx440245-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 488) |
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abx440526-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 565) |
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abx440807-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 594) |
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abx441088-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 633) |
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abx441369-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 655) |
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abx441650-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 680) |
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abx441931-100ug | Abbexa | 100 ug | 693.6 EUR |
Ankyrin R (ANK1) Antibody (ATTO 700) |
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abx442212-100ug | Abbexa | 100 ug | 693.6 EUR |
Ank1 sgRNA CRISPR Lentivector set (Mouse) |
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K3878001 | ABM | 3 x 1.0 ug | 406.8 EUR |
Mouse Ankyrin- 1, Ank1 ELISA KIT |
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ELI-49245m | Lifescience Market | 96 Tests | 1038 EUR |
Human Ankyrin- 1, ANK1 ELISA KIT |
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ELI-49312h | Lifescience Market | 96 Tests | 988.8 EUR |
ANK1 sgRNA CRISPR Lentivector set (Human) |
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K0086301 | ABM | 3 x 1.0 ug | 406.8 EUR |
Ank1 sgRNA CRISPR Lentivector set (Rat) |
|||
K6307301 | ABM | 3 x 1.0 ug | 406.8 EUR |
Guinea pig Ankyrin 1(ANK1) ELISA kit |
|||
E05A1448-192T | BlueGene | 192 tests | 1524 EUR |
Description: A sandwich ELISA for quantitative measurement of Guinea pig Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Guinea pig Ankyrin 1(ANK1) ELISA kit |
|||
E05A1448-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A sandwich ELISA for quantitative measurement of Guinea pig Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Guinea pig Ankyrin 1(ANK1) ELISA kit |
|||
E05A1448-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A sandwich ELISA for quantitative measurement of Guinea pig Ankyrin 1(ANK1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Ankyrin R (ANK1) Antibody (PE/ATTO 594) |
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abx443896-100ug | Abbexa | 100 ug | 710.4 EUR |
Polyclonal Ankyrin 1 / ANK1 Antibody (C-Term) |
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APG00534G | Leading Biology | 0.1mg | 580.8 EUR |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Ankyrin 1 / ANK1 (C-Term). This antibody is tested and proven to work in the following applications: |
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Ank1 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K3878002 | ABM | 1.0 ug DNA | 184.8 EUR |
Ank1 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K3878003 | ABM | 1.0 ug DNA | 184.8 EUR |
Ank1 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
|||
K3878004 | ABM | 1.0 ug DNA | 184.8 EUR |
ANK1 sgRNA CRISPR Lentivector (Human) (Target 1) |
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K0086302 | ABM | 1.0 ug DNA | 184.8 EUR |
ANK1 sgRNA CRISPR Lentivector (Human) (Target 2) |
|||
K0086303 | ABM | 1.0 ug DNA | 184.8 EUR |
ANK1 sgRNA CRISPR Lentivector (Human) (Target 3) |
|||
K0086304 | ABM | 1.0 ug DNA | 184.8 EUR |
Ank1 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6307302 | ABM | 1.0 ug DNA | 184.8 EUR |
Ank1 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6307303 | ABM | 1.0 ug DNA | 184.8 EUR |
Ank1 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K6307304 | ABM | 1.0 ug DNA | 184.8 EUR |
ANK1 Protein Vector (Human) (pPB-C-His) |
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PV001617 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPB-N-His) |
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PV001618 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPM-C-HA) |
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PV001619 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPM-C-His) |
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PV001620 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPB-C-His) |
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PV001621 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPB-N-His) |
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PV001622 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPM-C-HA) |
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PV001623 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPM-C-His) |
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PV001624 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Mouse) (pPB-C-His) |
|||
PV154374 | ABM | 500 ng | 3681.6 EUR |
ANK1 Protein Vector (Mouse) (pPB-N-His) |
|||
PV154375 | ABM | 500 ng | 3681.6 EUR |
ANK1 Protein Vector (Mouse) (pPM-C-HA) |
|||
PV154376 | ABM | 500 ng | 3681.6 EUR |
ANK1 Protein Vector (Mouse) (pPM-C-His) |
|||
PV154377 | ABM | 500 ng | 3681.6 EUR |
ANK1 Protein Vector (Mouse) (pPB-C-His) |
|||
PV154378 | ABM | 500 ng | 3788.4 EUR |
ANK1 Protein Vector (Mouse) (pPB-N-His) |
|||
PV154379 | ABM | 500 ng | 3788.4 EUR |
ANK1 Protein Vector (Mouse) (pPM-C-HA) |
|||
PV154380 | ABM | 500 ng | 3788.4 EUR |
ANK1 Protein Vector (Mouse) (pPM-C-His) |
|||
PV154381 | ABM | 500 ng | 3788.4 EUR |
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human) |
|||
4-PAB633Hu01 | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1) |
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ANK1 Protein Vector (Human) (pPB-His-MBP) |
|||
PV321786 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Human) (pPB-His-GST) |
|||
PV321787 | ABM | 500 ng | 394.8 EUR |
ANK1 Protein Vector (Rat) (pPB-C-His) |
|||
PV253566 | ABM | 500 ng | 3423.6 EUR |
ANK1 Protein Vector (Rat) (pPB-N-His) |
|||
PV253567 | ABM | 500 ng | 3423.6 EUR |
ANK1 Protein Vector (Rat) (pPM-C-HA) |
|||
PV253568 | ABM | 500 ng | 3423.6 EUR |
ANK1 Protein Vector (Rat) (pPM-C-His) |
|||
PV253569 | ABM | 500 ng | 3423.6 EUR |
ANK1 3'UTR Luciferase Stable Cell Line |
|||
TU000757 | ABM | 1.0 ml | 1825.2 EUR |
Ank1 3'UTR Luciferase Stable Cell Line |
|||
TU200614 | ABM | 1.0 ml | Ask for price |
Ank1 3'UTR GFP Stable Cell Line |
|||
TU250614 | ABM | 1.0 ml | Ask for price |
Ank1 3'UTR GFP Stable Cell Line |
|||
TU151791 | ABM | 1.0 ml | Ask for price |
Ank1 3'UTR Luciferase Stable Cell Line |
|||
TU101791 | ABM | 1.0 ml | Ask for price |
ANK1 3'UTR GFP Stable Cell Line |
|||
TU050757 | ABM | 1.0 ml | 1825.2 EUR |
ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
|||
LV669001 | ABM | 1.0 ug DNA | 3190.8 EUR |
ANK1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
|||
LV669005 | ABM | 1.0 ug DNA | 3190.8 EUR |
ANK1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
|||
LV669006 | ABM | 1.0 ug DNA | 3190.8 EUR |
Ank1 ELISA Kit| Mouse Ankyrin-1 ELISA Kit |
|||
EF014208 | Lifescience Market | 96 Tests | 826.8 EUR |
ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
LV707337 | ABM | 1.0 ug DNA | 379.2 EUR |
ANK1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC) |
|||
LV707341 | ABM | 1.0 ug DNA | 379.2 EUR |
ANK1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
|||
LV707342 | ABM | 1.0 ug DNA | 379.2 EUR |
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), APC |
|||
4-PAB633Hu01-APC | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with APC. |
|||
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), Biotinylated |
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4-PAB633Hu01-Biotin | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with Biotin. |
|||
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), Cy3 |
|||
4-PAB633Hu01-Cy3 | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with Cy3. |
|||
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), FITC |
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4-PAB633Hu01-FITC | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with FITC. |
|||
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), HRP |
|||
4-PAB633Hu01-HRP | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with HRP. |
|||
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), PE |
|||
4-PAB633Hu01-PE | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with PE. |
|||
Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody (Human), APC-Cy7 |
|||
4-PAB633Hu01-APC-Cy7 | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human Ankyrin 1, Erythrocytic (ANK1). This antibody is labeled with APC-Cy7. |
|||
ANK1 Protein Vector (Human) (pPM-N-D-C-HA) |
|||
PV321788 | ABM | 500 ng | 662.4 EUR |
ANK1 Protein Vector (Human) (pPM-N-D-C-His) |
|||
PV321789 | ABM | 500 ng | 662.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
|||
K3878005 | ABM | 3 x 1.0 ug | 451.2 EUR |
ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
|||
K0086305 | ABM | 3 x 1.0 ug | 451.2 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
|||
K6307305 | ABM | 3 x 1.0 ug | 451.2 EUR |
ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
|||
LV669002 | ABM | 1.0 ug DNA | 3190.8 EUR |
ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
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LV669003 | ABM | 1.0 ug DNA | 3260.4 EUR |
ANK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
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LV669004 | ABM | 1.0 ug DNA | 3260.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
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K3878006 | ABM | 1.0 ug DNA | 200.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
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K3878007 | ABM | 1.0 ug DNA | 200.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
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K3878008 | ABM | 1.0 ug DNA | 200.4 EUR |
ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
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K0086306 | ABM | 1.0 ug DNA | 200.4 EUR |
ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
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K0086307 | ABM | 1.0 ug DNA | 200.4 EUR |
ANK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
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K0086308 | ABM | 1.0 ug DNA | 200.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
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K6307306 | ABM | 1.0 ug DNA | 200.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
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K6307307 | ABM | 1.0 ug DNA | 200.4 EUR |
Ank1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
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K6307308 | ABM | 1.0 ug DNA | 200.4 EUR |
ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA) |
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LV707338 | ABM | 1.0 ug DNA | 379.2 EUR |
ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
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LV707339 | ABM | 1.0 ug DNA | 448.8 EUR |
ANK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
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LV707340 | ABM | 1.0 ug DNA | 448.8 EUR |
We apply this mannequin to a single cluster of inositol trisphosphate (IP 3) receptor channels and discover additional proof for the outcomes introduced in earlier work: a single cluster could also be succesful of producing completely different calcium launch sorts, the place long-lasting occasions are accompanied by unbinding of IP Three from the receptor (Rückl et al., PLoS Comput. Biol. 11, e1003965 (2015)).
Finally, we present the practicability of the mannequin in a grid of 64 clusters which is computationally intractable with earlier high-resolution fashions. Here long-lasting occasions can lead to synchronized oscillations and waves, whereas brief occasions keep localized. The frequency of calcium releases in addition to their coherence can thereby be regulated by the amplitude of IP Three stimulation. Finally the mannequin permits for a brand new rationalization of oscillating [IP 3], which isn’t based mostly on metabolic manufacturing and degradation of IP 3.